As, both PPARγ and C/EBP family members are the central modulators of adipogenesis and are widely studied targets in in vitro and in vivo studies of anti-obesogenic medicine, so, insights into various signaling pathways, energy sensing proteins (e.g., AMPK), genes and their transcriptional factors which have direct interactions with PPARγ and C/EBP family members are required to tackle abnormal adipose tissue development and obesity pandemic. This evidence concerns the gene PPARG and obesity disorder.