TNF and cardiovascular disorder: For example, inflammation in adipose tissue due to abnormal secretion of proinflammatory adipokines such as monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNFα), Interleukin 6 (IL 6) etc. is a key factor in the development of type 2 diabetes (T2D), insulin resistance, cardiovascular diseases and cancer (Burhans et al., 2011; Park et al., 2014).