HOTTIP and neoplasm: Ye et al. (2016) also found increased HOTTIP expression in GC tissues and cell lines, and correlated it with aggressive clinicopathological characteristics of GC patients. Chang et al. (2016) reported that HOTTIP was an oncogene in GC progression and downregulation of HOTTIP inhibits cell growth and impairs cell invasion and migration by reducing the expression of HOXA13. Recently, Sun et al. (2018) found that HOTTIP participates in tumor chemoresistance by acting as a competing endogenous RNA (ceRNA).