HOTTIP and neoplasm: Xu et al. (2019) showed that inhibition of autophagy significantly decreased Dex-induced tumor cell death and promoted chemoresistance in multiple myeloma. Evidence suggests that HOTTIP overexpression can inhibit autophagy in renal cell carcinoma (RCC) cells through the PI3K/Akt/Atg13 signaling pathway (Su et al., 2019).