When Tep1 is downregulated in glioma (repoGal4>UAS-PtenRNAi; UAS-RasV12; UAS-GFP/UAS-Tep1RNAi), both Mira (Figures 2C,C”) and Pros (Figures 2C,C”’) expression domains are restricted back to the central brain region. The gene discussed is PROS1; the disease is glioma.