However, when Tep1 is downregulated in the glioma (repoGal4>UAS-PtenRNAi; UAS-RasV12; UAS-GFP/UAS-Tep1RNAi), ex-lacZ expression as well as the number of glia are reduced (Figures 3F–F”). This evidence concerns the gene TEP1 and central nervous system cancer.