BRCA1 and breast cancer: Similarly, the BRACness phenotype, which is defined as any defect that impacts HR repair and phenocopies the mutation or loss BRCA1/2 (Byrum et al., 2019b), is also strongly linked with sensitivity to platinum and PARP inhibitors (Ding et al., 2019), especially in ovarian (Pillay et al., 2019) and breast cancer (Tung and Garber, 2018).