The Nrf2-ARE signaling pathway is considered a multiple-organ protective agent, playing a vital role in several CNS diseases, including subarachnoid hemorrhage (SAH), cerebral ischemia, traumatic brain injury and cerebral hemorrhage (Shih et al., 2005; Chen et al., 2011; Yin et al., 2015). Here, NFE2L2 is linked to Cerebral ischemia.