A member of the galectin family of proteins which modulate proliferation and cell-cell/cell-matrix interactions, upregulation of LGALS1 expression in breast cancer adjacent fibroblasts has been linked to metastasis and is altered in lymph node metastases compared to primary breast tumors (Feng et al., 2007; Folgueira et al., 2013). The gene discussed is LGALS1; the disease is breast cancer.