SOX2 and familial pancreatic carcinoma: Furthermore, overexpression of SOX2 correlates to gemcitabine resistance in pancreatic cancer cells (Jia et al., 2019), as well as higher malignancy in glioblastoma, esophageal, breast, and prostate cancers (Annovazzi et al., 2011; Jia et al., 2011; Wuebben and Rizzino, 2017).