AKT1 and cancer: The FGFR family consists of four highly conserved transmembrane RTKs (FGFR1–4) and their aberrant activation gives rise to the activation of many cancer-related pathways, such as MAPK, PLCγ, PI3K/AKT, JAK/STAT (Ornitz and Itoh, 2015; Touat et al., 2015).