In this study, we aim to demonstrate the genomic landscape of ALK fusion-positive tumors in 44 Chinese NSCLC patients sequenced with our customized HapOncoCDx panel which involves hybridization capture and deep sequencing of all protein-coding exons of 464 cancer-associated genes and other selected introns of other oncogenes and tumor suppressor genes, and illustrate their genomic mutation patterns and characteristics, which potentially helps to develop treatment strategy. The gene discussed is ALK; the disease is non-small cell lung carcinoma.