By use of cell culture and nude mice xenograft model, Du et al. claimed that EVs released by human Wharton's jelly mesenchymal stem cells induced HGF expression, activated AKT and ERK1/2 signaling pathways, then promoted the proliferation and aggressiveness of RCC cells both in vitro and in vivo (66). The gene discussed is AKT1; the disease is renal cell carcinoma.