These transporters, including the Na+/H+ exchanger NHE1 (SLC9A1) and the Na+, HCO3- cotransporters NBCn1 (SLC4A7) and NBCe2 (SLC4A5) confer additional advantages to the cancer cells, including stimulation of proliferation, survival, and invasiveness, leading to increased tumor growth and metastasis (21–24). Here, SLC9A1 is linked to neoplasm.