SLC4A5 and cancer: These transporters, including the Na+/H+ exchanger NHE1 (SLC9A1) and the Na+, HCO3- cotransporters NBCn1 (SLC4A7) and NBCe2 (SLC4A5) confer additional advantages to the cancer cells, including stimulation of proliferation, survival, and invasiveness, leading to increased tumor growth and metastasis (21–24).