As shown in Figure 4, B cell related l mediated immunity, humoral immune response, innate immune response, lymphocyte mediated immunity Gene ontology terms (Supplementary Figure 2), antigen processing and presentation, the JAK-STAT signaling pathway, natural killer cell mediated cytotoxicity, toll-like receptor signaling pathway, primary immunodeficiency etc. pathways (Supplementary Figure 3) were enriched in the HIST1H2BK high expression phenotype. The gene discussed is SOAT1; the disease is inborn error of immunity.