NOTCH1 and neoplasm: Mutations occurred less frequently (<1.5%) in the other 11 genes (CTNNB1, AKT1, ERBB2, ERBB4, FGFR1, ALK, MAP2K1, NOTCH1, DDR2, FGFR3, and FGFR2), consistent with the “tail effect” associated with NGS profiling of tumor samples (15) (Figure 1A).