Mutations occurred less frequently (<1.5%) in the other 11 genes (CTNNB1, AKT1, ERBB2, ERBB4, FGFR1, ALK, MAP2K1, NOTCH1, DDR2, FGFR3, and FGFR2), consistent with the “tail effect” associated with NGS profiling of tumor samples (15) (Figure 1A). Here, MAP2K1 is linked to neoplasm.