Several molecular targeting agents including immunomodulatory agents, proteasome inhibitors, PI3K and Akt inhibitors, novel anti-CD20 monoclonal antibodies, and immune checkpoint inhibitors seem to have a therapeutic potential, providing a strong rationale for new clinical trials to improve the outcome of EBV post-transplant lymphoproliferative disorder. The gene discussed is AKT1; the disease is lymphoproliferative syndrome.