Long and Campbell (2017) reported that male patients with low expression of galactin 4 (LGALS4) had significantly shortened disease-free survival in colon cancer. Caspase-7 (CASP7) plays an important role in the autophagy and apoptosis of colon cancer (Athamneh et al., 2017). Additionally, CASP7 polymorphism is highly responsible for poor outcomes in patients with surgically resected colorectal cancer (Chae et al., 2011). Here, LGALS4 is linked to colonic neoplasm.