Although we do not fully understand the mechanisms by which endothelial HSPA12B regulates the infiltration of monocytes/macrophages into the tissues during polymicrobial sepsis at present, we observed that the levels of adhesion molecules in the myocardium were markedly increased in HSPA12B–/– septic mice compared with WT septic mice. The gene discussed is HSPA12B; the disease is Sepsis.