Galectin-9 is a particularly promising target in allergy prevention strategies, as exposure of intestinal epithelial cells to scGOS/lcFOS together with bacterial CpG DNA or synthetic CpG ODN promoted the secretion of galectin-9 in vitro, which resulted in enhanced secretion of IFNγ and IL-10 production by underlying immune cells (154, 157). The gene discussed is LGALS9; the disease is allergic disease.