CD274 and neoplasm: This could explain the success of combinatory treatments with anti-angiogenic drugs and PD-1 or PD-L1 blockade in mouse tumor models (70, 136), which relies on the normalization of the tumor vasculature (136) and promotion of high endothelial venules (70), a vessel type specialized in lymphocyte trafficking and found in secondary lymphoid organs and TLS (137).