F8 and hemophilia A: In a study among 42 patients with severe and moderate hemophilia A, the presence of high-titer FVIII-specific NNAs was associated with reduced FVIII half-life in comparison to patients without NNAs (median 7.8 h, IQR 6.6–9.2 vs. 10.4 h, IQR 8.9–13.8) (20).