GK and corneal infection: Also, gK was discovered to be responsible for the spread of HSV from the corneal epithelium to the neurons, suggesting that gK is important for the establishment of latency as corneal infection with HSV-1 that had a mutation in the N-terminus of gK, failed to infect the trigeminal ganglia in mice (David et al., 2008, 2012; Saied et al., 2014).