According to a update of the MDS Research Criteria for Prodromal Parkinson's Disease by Heinzel et al. (46) several imaging approaches have potential as sensitive and specific markers of prodromal PD as suggested by associations with RBD, GBA, or LRRK2 mutation carriers, Dementia with Lewy Bodies, and PD. This evidence concerns the gene LRRK2 and Parkinson disease.