In one of the largest studies using DAT- SPECT, a prospective study of 43 iRBD patients, Iranzo et al. (12) found that decreased striatal DAT uptake (123I-FP-CIT binding) and substantia nigra hyperechogenicity might be useful markers to identify individuals at increased risk for developing synucleinopathies. The gene discussed is SLC6A3; the disease is synucleinopathy.