MC4R and obesity due to melanocortin 4 receptor deficiency: In addition, it is necessary to investigate other genes (isolated or associated) which have been demonstrated to be involved in obesity such as FTO (Ben Halima et al., 2018), Melanocortin 4 Receptor - MC4R (Resende et al., 2017), Adenovirus 36 (Zhou et al., 2018) and beta 2 adrenoceptor-ADRB2 (Daghestani et al., 2018).