a.Patients with hypertension: Periodic determination of blood pressure is recommended, especially in hypertensive patients.b.Urinary retention may occur in patients with Bladder Outlet Obstructionc.Urinary retention may occur in patients taking muscarinic antagonist medications for the treatment of OABd.Angioedema: Angioedema may occur after the first dose of mirabegrone.Drugs Metabolized by CYP2D6: Appropriate monitoring and dose adjustment may be necessary, with drugs metabolized by CYP2D6, such as thioridazine, flecainide, and propafenone. The gene discussed is CYP2D6; the disease is hypertensive disorder.