a. Large PVR and/or severely diminished urinary flow may not be good candidates for 5-ARIs therapyb. Men being treated with dutasteride should not donate blood until at least 6 months have passed following their last dose.c. Caution should be used in the administration of dutasteride to patients with liver diseased. Care should be taken when administering dutasteride to patients taking potent, chronic CYP3A4 enzyme inhibitors(e.g., ritonavir). Here, CYP3A4 is linked to liver disorder.