KLK3 and prostate carcinoma: a.5-ARIs are suitable only for long-term treatment (years), because of the slow onset of action.b.The effect of 5-ARIs on the serum PSA concentration needs to be considered in relation to prostate carcinoma screening and PSA measure.c.Exposure of Women-Risk to Male Fetus: women who are pregnant or may be pregnant should not handle.d.5-ARIs are not indicated for use in women and children.