TRH and Cognitive impairment: In vivo, TRH, or some analogs, activate the septo-hippocampal and basalis cortical cholinergic systems, eliciting acetylcholine release onto the hippocampus and cortex and restore cognitive deficits of animals with lesions in the medial septum (Itoh et al., 1994; Bennett et al., 1997; Horita, 1998; Prokai-Tatrai and Prokai, 2009; Daimon et al., 2013).