We found that the mRNA and protein expression of BRD4 were markedly upregulated in caerulein hyperstimulation pancreatitis, L-arginine-induced pancreatitis representing severe form of AP (Dawra et al., 2007), fatty acid ethyl ester pancreatitis mimicking alcohol associated acute pancreatitis (Huang et al., 2014), and NaT pancreatitis mimicking biliary acute pancreatitis (Perides et al., 2010) (Figures 1A–C). This evidence concerns the gene BRD4 and alcohol dependence.