In this way, while in P-gp-overexpressing cancer cells, CS agents seem to be related to diverse biochemical mechanisms, in MRP1-overexpressing cancer cells, CS agents appeared to behave as stimulators of glutathione efflux, altering redox balance and thus triggering apoptosis of multi-resistant cells (Klukovits and Krajcsi, 2015). This evidence concerns the gene ABCC1 and cancer.