NOTCH3 and cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1: Muino et al. (2017) recently reviewed cysteine-sparing NOTCH3 missense mutations and proposed criteria for their pathogenicity: (a) typical clinical CADASIL syndrome; (b) diffuse white matter hyperintensity (WMH); (c) 33 NOTCH3 exons analyzed; (d) mutations that were not polymorphisms; and (e) GOM deposits noted in skin biopsy.