The reduced general activity of PDK1 exhibited by the hypomorphic PDK1 mice (PDK1hm) results in several behavioral differences related to anxiety and exploration assessed in various tests (Ackermann et al., 2008), while cognitively unimpaired Akt2 knockout mice (Akt2−/−) presented an anxiety- and depressive-like phenotype (Leibrock et al., 2013). This evidence concerns the gene PDK1 and Anxiety.