Indeed, the earliest identified microcephaly associated genes were implicated in centrosome biogenesis, and spindle assembly, which include molecules such as CDK5RAP2, CPAP, Cep135, Cep152, PCNT, and MCPH1 where the mutations in these genes were identified in consanguineous populations inherited via an autosomal recessive fashion (Bond et al., 2002; Bond et al., 2005; Rauch et al., 2008; Guernsey et al., 2010; Hussain et al., 2012). The gene discussed is CDK5RAP2; the disease is microcephaly.