Our finding of reduced axonal transport in iPS-neurons derived from SPAST patients concurs with findings of studies involving post-mortem spinal cord analysis (Kasher et al., 2009) and iPS-neurons (Denton et al., 2014; Havlicek et al., 2014), showing that we were able to recapitulate HSP pathology in our neurons. The gene discussed is SPAST; the disease is hereditary spastic paraplegia.