Beside the Chompret criteria, recent reports and experience of certain centres justify to extend TP53 testing to other clinical presentations suggestive of a germline TP53 alteration: Children and adolescents with hypodiploid acute lymphoblastic leukaemia [15, 16], otherwise unexplained sonic hedgehog-driven medulloblastoma [17], jaw osteosarcoma (see below recommendation 2) and patients who develop a second primary tumour within the radiotherapy field of a first core TP53 tumour which occurred before 46 years (see below recommendation 3). This evidence concerns the gene TP53 and acute lymphoblastic leukemia.