Furthermore, RIPK3 depletion reversed the effect of Beclin 1 depletion on tumour growth, which was induced by treatment with birinapant and emricasan, suggesting that depletion of Beclin 1 might be accelerating the necroptotic processes in the tumour model (Fig. 8e–i and Supplementary Fig. 7i). The gene discussed is RIPK3; the disease is neoplasm.