However, we and others have previously demonstrated that wild-type IDH2 (IDH2 WT) produces 2HG in breast cancer cells; i.e., in HTB-126/Hs578T cells, 2HG is readily formed in the absence of known IDH2 mutations, and IDH2 WT was identified to be responsible for its substantiate part11,12. This evidence concerns the gene IDH2 and breast carcinoma.