The Cancer Genome Atlas (TCGA) data set21 revealed that MDFI mRNA was significantly upregulated in cecum, colon, colon mucinous, rectal and rectal mucinous adenocarcinomas compared to normal colon and rectum (Fig. 2a), while MDFIC was on average downregulated (Fig. 2b). The gene discussed is MDFI; the disease is rectum mucinous adenocarcinoma.