It is as well conceivable that MDFI and MDFIC regulate JMJD1A activity in the cytoplasm, since this histone demethylase is also present to a large extent in the cytoplasm of colon cancer cells19 where it may potentially demethylate cytoplasmic, non-histone proteins. The gene discussed is KDM3A; the disease is malignant colon neoplasm.