FOXP3 and infection: In addition to FoxP3, Tregs can express Th master TFs T-bet, RORγT, or GATA3.19–22 The role of these Treg TFs is the subject of ongoing research and accumulating evidence suggests that Tregs expressing Th TFs may selectively suppress their respective Th subset.21,23,24 T-bet+ Tregs can selectively target Th1 cells, but it is unclear whether Tregs expressing other TFs have similarly selective functions.21,24 It is also unclear whether selective suppression can alter the balance of Th cell responses during infection.