Murine eosinophil-associated ribonucleases (Ear) molecules are paralogues of human eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN), and are associated with asthma.22–24 Assays have suggested diverse roles including chemotactic,25 bactericidal,26 anti-viral,27,28, and anti-helminthic29 activities in vitro. This evidence concerns the gene RNASE3 and asthma.