Human EDN and ECP are induced by type-2 immunity22–24 and have been reported to possess chemotactic activities in vitro.25 Furthermore, Ear11 has been proposed to act in vitro as a chemoattractant for macrophages.35 Although mouse Ear11 expression has been reported in lung alveolar macrophages in models of allergic asthma and following the administration of IL-25 or IL-33, little is known about the functional roles of Ear11 in vivo. This evidence concerns the gene IL33 and allergic asthma.