CASP12 and Hyperglycemia: Chowdhury et al. showed that FA is sufficiently potent to provide protection to the heart from oxidative and endoplasmic reticulum stress by circumventing hyperglycemia, ameliorating cardiac damage markers, regulating the intracellular redox balance, and attenuating the eIF-2a- and caspase 12-activated endoplasmic reticulum stress-induced apoptotic pathway in streptozotocin-induced diabetic rats38.