Gene expression profiling (GEP) of sorted T-cells from peripheral blood mononuclear cells (PBMCs) of CLL patients suggested that CD4+ T-cells are skewed toward a Th2 phenotype due to decreased expression of c-Jun NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) pathway-related genes [12]. This evidence concerns the gene CD4 and B-cell chronic lymphocytic leukemia.