CCR5 expressed in neoplastic cells contributes to cell migration, invasion and tumor progression not only via the CCL3–CCR5 axis [20, 21, 23, 27], but also via the CCL5–CCR5 axis in breast cancer, pancreatic cancer, salivary adenoid cystic carcinoma, Hodgkin lymphoma, and ESCC [31–38]. The gene discussed is CCL5; the disease is esophageal squamous cell carcinoma.