Among the upregulated molecules in the TAM-like macrophages, we observed that growth differentiation factor 15, neural cell adhesion molecule, and CXC chemokine ligand 8 (CXCL8, also known as IL-8) contribute to the tumor cell migration, progression, and poor prognosis of ESCC [13–15]. This evidence concerns the gene CXCL8 and esophageal squamous cell carcinoma.