CCR5 and osteosarcoma: For example, the CCL3–CCR1 axis has been associated with the progression of hepatocellular carcinoma [17], whereas the CCL3–CCR5 axis has been associated with osteolysis in multiple myeloma [18, 19], lung metastasis in murine renal cell carcinoma [20], cell migration, and invasion in chondrosarcoma [21], infiltration of cancer-associated fibroblasts in murine colitis-associated colorectal carcinoma [22], and angiogenesis in osteosarcoma [23].