In this study, we focused on the potential role of p190A in EMT, an evolutionarily conserved developmental process that has been implicated in tumorigenesis and confers metastatic features upon cancer cells by enhancing migration, invasion, and apoptotic resistance.12 Gene set enrichment analysis (GSEA) showed that p190A KO upregulated the EMT gene signature in Ishikawa cells (Fig. 3d, e). The gene discussed is ARHGAP35; the disease is cancer.