RHOA and neoplasm: Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate the cellular responses required for cell migration, cell polarity, and cell cycle progression.3,4 RhoA is one of the most well-characterized Rho GTPase family members and has long been involved in malignant transformation, tumor invasion, and metastasis.5 The activity of Rho GTPases is regulated by GTPase-activating proteins (GAPs) and guanine nucleotide-exchange factors (GEFs).