p190A RhoGAP (hereafter p190A) is the most widely studied RhoGAP and is generally regarded as the main RhoGAP for RhoA in cells.6 p190A is also associated with cell migration, epithelial differentiation, polarity, cell–cell junctions, and cell division.6 Importantly, ARHGAP35, the gene encoding p190A, was found to be frequently mutated in up to 15% of endometrial cancers and 2% of all tumors in a studied cohort.7,8. Here, ARHGAP1 is linked to endometrial cancer.