5XFAD mice, carrying a 3’-UTR modified human TNF-α (hu TNF-α) transgene23 (5XFAD/Tg197) that results in increased peripheral expression of huTNF-α protein, develop an AD-like phenotype along with TNF-induced inflammatory arthritis, which can be suppressed by peripheral treatment with infliximab, a monoclonal anti-huTNF-α antibody widely used for RA treatment in patients24. Here, TNF is linked to rheumatoid arthritis.