IL1B and Netherton syndrome: Several differences were observed between the phenotype of the Spink5ko mice used in this study (Yang et al., 2004) and other Netherton syndrome mouse models (Descargues et al., 2005; Furio et al., 2015), including a more generalized detachment of the stratum corneum concomitant with a normal expression of some pro-inflammatory markers, such as Il1b, and the lack of an inflammatory cell infiltrate.