Abnormal cytoplasmic aggregates of TDP-43 in degenerating neurons are being recognized as a hallmark of ALS, frontotemporal lobar degeneration (FTLD), and limbic-predominant age-related TDP-43 encephalopathy (Neumann et al., 2006; Nelson et al., 2019). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.