It is widely acknowledged that deregulated NF-κB signaling may contribute to acute neurodegenerative conditions, such as cerebral ischemia and traumatic brain injury (Harari and Liao, 2010) as well as chronic neurodegenerative disorders, such as Alzheimer's disease (Jones and Kounatidis, 2017), Parkinson's disease (Flood et al., 2011), Huntington's disease (Bečanović et al., 2015), and ALS (Sako et al., 2012). The gene discussed is NFKB1; the disease is amyotrophic lateral sclerosis.