HMGB1 and cancer: The most relevant ICD-associated DAMPs considering the clinical response of cancer cells are (1) the pre-apoptotic exposure of chaperones on the cell surface - mainly calreticulin (CRT); (2) the secretion of adenosine triphosphate (ATP); and (3) the post-apoptotic release of High Mobility Group Box 1 protein (HMGB1) to the environment [18–20].