An interaction between diabetes and the polymorphisms of hexokinase 2 (HK2), a glucose metabolism gene, on the risk of pancreatic cancer was reported, with HK2 R844K GA/AA genotype showing an inverse association with pancreatic cancer among individuals without diabetes, but a positive association with pancreatic cancer among diabetic patients [37]. The gene discussed is HK2; the disease is familial pancreatic carcinoma.