Interestingly, the conversion of CD4+CD25− T cells to CD4+CD25+Foxp3+ Tregs was significantly increased when normal or AML CD4+CD25− T cells were cocultured with AML Bregs (2.31 ± 0.27% vs. 7.53 ± 0.65%, P = 0.0018; 1.89 ± 0.32% vs. 12.77 ± 1.63%, P = 0.0028). Here, CD4 is linked to acute myeloid leukemia.