CXCR4 and acute myeloid leukemia: As SDF-1α/CXCR4 is crucial for Treg migration to BM and an alternate SDF-1α receptor, CXCR7, still needs to be investigated [14, 19], we first designed a chemotaxis assay to exclude the effect of other soluble chemoattractants in BM fluid from AML patients on Treg migration.