HH inhibitors block both intrinsic signaling in cancer cells as well asextrinsic signaling to stromal cells to reduce tumor growth.17,18 Therefore,tumorigenesis, tumor progression, and therapeutic responses have been shown to beaffected by the SHH signaling pathway.7 Taken together, HH pathways have been identified as key players in humancancers including NSCLCs. The gene discussed is SHH; the disease is neoplasm.