The aggressiveness of NSCLC has been suggestedto be associated with the acquisition of epithelial-to-mesenchymal transition (EMT).15 In other research, A549 lung adenocarcinoma cells that obtain mesenchymalphenotype show upregulated SHH and GLI1 expression compared with A549 cells. This evidence concerns the gene GLI1 and non-small cell lung carcinoma.