Currently, studies are ongoing to evaluate the potential role of HH inhibitors assolid tumor targeted therapies, for example, in NSCLC.47 To further investigate whether SMO/PTCH1/GLI1, GLI2 were functionallylinked to caspase signaling, we examined the effect SMO/PTCH1 on activation ofGLIs. The gene discussed is PTCH1; the disease is non-small cell lung carcinoma.