Signaling pathways operative during organ development, including SHH andassociated GLI transcription factors (GLI 1-3), have recently been found to bereactivated in NSCLC.1 Therefore, we confirmed the alteration of SMO, PTCH1, and GLI1/2expression by C militaris in the NSCLC cells. This evidence concerns the gene PTCH1 and non-small cell lung carcinoma.