EGF and glioblastoma: It was demonstrated that HGGs express some transcriptional alterations in angiogenesis-associated factors, such as VEGF, fibroblast growth factor (FGF), and epidermal growth factor (EGF), that correlate with neovascularization in human GBM samples [168], and the upregulation of these genes may also play a role in activating the angiogenic switch.