Interestingly, it was revealed that CXCL12 may induce a significant increase of DNA synthesis in primary human glioblastoma cell cultures and chemotaxis in a glioblastoma cell line [204], what proves that this chemokine contributes not only to chemotactic spread of tumor cells, but also induces proliferation of malignant cells. This evidence concerns the gene CXCL12 and neoplasm.