ACKR3 and glioblastoma: In addition, a pro-tumoral function of ACKR3 was confirmed in a murine model of glioblastoma ACKR3, where anti-ACKR3 monoclonal antibodies used in combination with temozolomide, a chemotherapy agent, activated immune responses, induced the phagocytic activity of macrophages and the cytotoxic activity of NK cells and complement, what resulted in extended survival of mice [311].