Furthermore, TGFB3 mutations in Loeys-Dietz Syndrome 5 (LDS5)/Rienhoff syndrome (RNHF) (OMIM#615582) are associated with connective tissue disorders and Marfan syndrome (MFS)-like features, including congenital heart defects (CHD), aortic aneurysms, and valvular disease [9,10,11]. Here, TGFB3 is linked to Marfan syndrome.