LMNA and Emery-Dreifuss muscular dystrophy: Mattout et al. found an impaired sequestration of heterochromatin at the NE level and down regulation of at least 24 muscle-specific genes, in LMN-1 Y59C-expressing worms, linked to an autosomal-dominant form of Emery-Dreifuss muscular dystrophy in human [236].