Moiseeva et al. proposed a self-reinforcing aging mechanism, based on the defective lamin A Ser22 phosphorylation site exhibited in HGPS cells; they suggested that a small accumulation of progerin inhibits the Ser22 phosphorylation site in lamin A, thus preventing Cdk 4/6-kinase activity during interphase. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.