To further define the link between p53 and the tumor exosome-mediated M2 polarization, THP-1-M0 macrophages were co-cultured with H358 exosomes in a 10:1 (10 exosomes/cell) ratio for 72 h and then stained with CD11b, CD163 and CD206. This evidence concerns the gene TP53 and neoplasm.